Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis

Journal of BIOPHOTONICS 2018 I https://doi.org/10.1002/jbio.201800154

Ewa Maczynska, Karol Karnowski, Krzysztof Szulzycki, Monika Malinowska, Hubert Dolezyczek, Artur Cichanski, Maciej Wojtkowski, Bartlomiej Kaluzny, Ireneusz Grulkowski


Application of the air-puff swept source optical coherence tomography (SS-OCT) instrument to determine the influence of viscoelasticity on the relation between overall the air-puff force and corneal apex displacement of porcine corneas ex vivo is demonstrated. Simultaneous recording of timeevolution of the tissue displacement and air pulse stimulus allows obtaining valuable information related in part to the mechanical properties of the cornea. A novel approach based on quantitative analysis of the corneal hysteresis of OCT data is presented. The corneal response to the air pulse is assessed for different well-controlled intraocular pressure (IOP) levels and for the progression of cross-linking-induced stiffness of the cornea. Micrometer resolution, fast acquisition and noncontact character of the air-puff SS-OCT measurements have potential to improve the in vivo assessment of mechanical properties of the human corneas.

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This project has received funding from the European Union’s
Horizon 2020 research and innovation programme
under grant agreement No 666295.