Spatio-Temporal Optical Coherence Imaging–a new tool for in vivo microscopy

Photonics Letters of Poland 2019 | 11 (2) | 44

Maciej Wojtkowski, Patrycjusz Stremplewski, Egidijus Auksorius, Dawid Borycki


Optical Coherence Imaging (OCI) including Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) uses interferometric detection to generatehigh-resolution volumetric images of the sample at high speeds. Suchcapabilities are significant for in vivo imaging, including ophthalmology, brain,intravascular imaging, as well asendoscopic examination. Instrumentation and software development allowed to create many clinical instruments. Nevertheless, most of OCI setupsscan the incident light laterally. Hence, OCI can be further extended by wide-field illumination and detection. This approach, however, isvery susceptible to the so-called crosstalk-generated noise. Here, we describe our novel approach to overcome this issue with spatio-temporal optical coherence manipulation (STOC), which employs spatial phase modulation of the incident light.

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This project has received funding from the European Union’s
Horizon 2020 research and innovation programme
under grant agreement No 666295.