This visit was scheduled in cooperation with one of the best group in the field of ultrafast Optical Coherence Tomography (OCT) – prof. Huber group from Lubeck. The purpose of the visit was to obtain results from ultrafast (up to 100 vol./s) OCT on rabbit and mice hearts. In order to do that, we have made a cooperation with Max Planck for Dynamics and Self-Organization from Goettingen, which gave us a support from biological point of view (also provided with well-prepared hearts).
The goal of the visit was to carry first in the world investigation of full heart with use of OCT system. For that Michał Hamkało had to get newly extracted hearts of mice from an authorized laboratory in Goettingen and took it to Luebeck (to next cooperator) with help of dr Jan Christoph. In the Institute for Biomedical Optics in Luebeck he was working with the OCT system (one of the fastest in the world) in order to specify parameters of heart imaging.
The goal of the visit was to perform experiments on human cells using novel microscopic technique: differential dynamic microscopy (DDM). The plan of the experiments contained quantification of movement of subcellular components in native HeLa cells and observation of changes of mobility during programmed cell death (apoptosis).
The purpose of the travel was to assess the perspectives for future collaboration with the Soft Living Matter Group run by prof. Clifford Brangwynne at the Princeton University. The group conducts cutting-edge research in the field of physicochemistry of soft matter in living systems. The group possesses a wide background and know-how concerning biophysical studies on model biological systems at all complexity levels (single cells, tissues and organisms). It is applied there, i.e., to studies of phase transitions in living systems and intrinsically disordered proteins, which play a key role in the pathogenesis of neurodegenerative diseases.
Professor Maciej Wojtkowski (the ERA Chair holder, the Head of the Department of Physical Chemistry of Biological Systems) accompanied by the:Director of the Institute of Physical Chemistry PAS - professor Marcin Opallo, President of the Scientific Council of IPC - professor Aleksander Jablonski Project Coordinator - professor Robert Holyst, and former postdoc at Professor Holyst Group – Associate Professor Hou Sen, linking person with Nankai University,
visited Nankai University in Tianjin, China (the 6 – 8th March, 2017).
This conference served as part of the SPIE Photonics West 2017 - the world's largest multidisciplinary event for photonics technologies collocated with one of the largest photonic exhibition.
On the 20 – 21 Oct., 2016 Professor Pavel Jungwirth from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences came to IPC. On the first day Professor Jungwirth delivered an open for all IPC researchers (incl. PhD students) lecture: “Exploring Hydrated Electrons in Non-Conventional and Conventional Ways: From Alkali Metal Explosions to Non-Explosive Ways”. The lecture was aimed at stimulating creativity and curiosity of the IPC society as regards to selected research topics and drawing inspiration for research from everyday life.
The purpose of this business trip was to perform collaborative work on the interferometric near-infrared spectroscopy (iNIRS). More specifically, experiments to quantify optical properties in dynamic media were performed. Then, the data was processed numerically using the new method of correlation gating to separate ballistic and scattered light transmitted through thick samples.
Two-photon excitation fluorescence (TPEF) imaging of the back of the eye allows visualization of subcellular structures in the living animal eye. This method is helpful for investigating mechanisms of retinal diseases and development of ophthalmic therapies. Endogenous fluorophores, necessary for replenishing visual chromophore, and thus sustaining vision have absorption maxima in the range from 320 – 400 nm. However, anterior optics of the animal eye poorly transmit light at those wavelengths. Two-photon excitation fluorescence imaging employing 75 fs laser pulses overcomes this barrier and visualizes subcellular organelles in the living animal eye.
Working visit to Optical Biomedical Imaging Group Institute of Physics, Nicolaus Co-pernicus University.
The visit to Optical Biomedical Imaging Group Institute of Physics, Nicolaus Copernicus University was to have the deep analysis of the in-vivo imaging of the global mouse brain ischemia (GI) using Bessel beam optical coherence microscopy. This method allows to monitor changes in brain structure with extra control of blood flow during the process of artery occlusion. The results showed the capability and sensitivity of OCM system with Bessel beam to analyze brain plasticity after severe injury within a period of 8 days.